Biopharmaceutical Section's Web-based Training Series 2011

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Group Sequential Design Basics with Application using the gsDesign R Package and its GUI

Presented by Dr. Keaven Anderson (Merck & Company, Inc.) on February 23, 2011 (noon-2:00 Eastern time).

Group sequential design is a well-accepted method of adaptive design. This course covers several essential technical aspects of the asymptotic theory and application of group sequential design. The gsDesign R package and its GUI, gsDesignExplorer, will be used to demonstrate these principles. Topics covered include: control of Type I and II error, boundary family and spending function approaches to design. Aspects of interim analysis to be discussed include confidence intervals, B-values, conditional and predictive power. Applications to trials with binomial and time-to-event outcomes will be used for illustration.

Handouts

Download handouts.

Other files

Download software installation notes.

Download GSD file.

Download R code.

gsDesign R Package

Visit GsDesign Package for more information about the R package (gsDesign) and graphical user interface (gsDesignExplorer) featured in this webinar.