Main page > Innovation > Flexible designs > PhRMA adaptive dose-ranging studies working group

This page is maintained by the PhRMA adaptive dose-ranging studies working group (Alex Dmitrienko).

Key presentations given by members of the Working Group.

PhRMA Critical Path Initiatives: Rolling Dose Studies
José Pinheiro (Novartis) and Rick Sax (AstraZeneca) on behalf of the ADRS Working Group. ENAR Meeting, Tampa, FL, March 27, 2006 [Download slides].

PhRMA PISC Working Group on Rolling Dose Studies: Results, Conclusions and Recommendations
José Pinheiro (Novartis), July 7, 2006 [Download slides].

Adaptive Dose Ranging Studies: Flexible, Adaptive Dose-Finding Designs
Frank Bretz and José Pinheiro (Novartis), Tokyo University of Science, Tokyo, Japan, July 28, 2006 [Download slides].

Evaluating Rolling Dose Designs and Methods
Amit Roy and Frank Shen (Bristol-Myers Squibb), Joint Statistical Meetings, Seattle, WA, August 6-10, 2006 [Download slides].

Scenario Planning: Comparing Methods, Quantifying Potential Gains from Adaptive Dose-Finding Designs
José Pinheiro (Novartis), PhRMA/FDA Adaptive Designs Workshop, Washington, DC, November 13, 2006 [Download slides].

Adaptive Dose Ranging Studies to Establish Dose Response: Case Studies and Computer Simulations
José Pinheiro (Novartis), ICDD Conference, Austin, TX, February 14, 2007 [Download slides].

PhRMA Adaptive Dose-Ranging Studies Working Group
FDA meeting, May 2, 2007 [Download slides].

Adaptive Dose Ranging Studies
Frank Bretz and José Pinheiro (Novartis), DAGStat Annual Meeting, Bielefeld, March 29, 2007 [Download slides].

Innovative Approaches for Designing and Analyzing Adaptive Dose-Ranging Trials
Amit Roy (Bristol-Myers Squibb), PharmaEd Resources Conference on Adaptive Trial Designs, Philadelphia, PA, September 10-11, 2007 [Download slides].

Estimating the interesting part of a dose-effect curve: When is a Bayesian adaptive design useful?
Frank Miller (AstraZeneca), Multiple Comparison Procedures Conference, Vienna, Austria, July 11, 2007 [Download slides].

Accelerating Clinical Development With Adaptive Study Designs
Amit Roy (Bristol-Myers Squibb), Annual Symposium of Korean Research-based Pharmaceutical Industry Association (KRPIA) -- Role of Korea in Global Drug Development, Seoul, Korea, November 23, 2007 [Download slides].

Impact of Dose Selection Strategies on the Probability of Success in the Phase III
Zoran Antonijevic (Quintiles), Adaptive Designs for Clinical Trials, Boston, MA, April 21, 2008 [Download slides].